Duromine is used as an effective drug for weight loss. Its capsules may contain 15 mg, 30 mg or 40 mg of the active ingredient Phentermine. It sometimes happens so that even the maximum Duromine dose of 40 mg does not work for weight loss. Why is this happening?

Despite the fact that Duromine has been successfully used for many years for weight reduction, the exact mechanism of its action is not completely understood.

The drug belongs to the pharmaceutical class of sympathomimetics.

Duromine has the main impact on the noradrenergic and dopaminergic receptors, which are capable of controlling your appetite. However, the release of the neurotransmitters dopamine and norepinephrine has not only the anorectic effect.

By its effects on the body, the anorectic is similar to amphetamines.

Therefore, one of the reasons that a high dose of 40 mg Duromine does not work is the development of tolerance or dependence.

The accumulation of the neurotransmitters in the brain contributes to such effects, as tension, anxiety, insomnia, muscle pain, vomiting, or diarrhea. These unwanted reactions may be the first signs of physical dependence for the drug.

Tolerance or dependence is a state of the body, in which Duromine has no therapeutic effect, i.e. appetite suppression and weight loss.

  • Formation of Duromine tolerance may start with 15 mg.

You will need to increase the dose to 30 mg and then to 40 mg per day. In the end, the maximum dose of 40 mg Duromine stops working and becomes useless for weight loss.

If your body develops tolerance, high Duromine dose of 40 mg stops working after 2-4 weeks of regular use. Since 40 mg is the maximum tolerated dose of the anorectic, further increase in dosage becomes potentially dangerous to health.

  • Getting used to Duromine action is possible not only with time.

For some people, the anorectic effect is not achieved neither after the first use of the drug, nor in the further use of the anorectic. The first dose of 40 mg Duromine does not work, if the patient used psychostimulant drugs before.

What to do, if the dose of 40 mg Duromine does not work for weight loss:

Use another weight loss drugUse non-drug weight loss methodsAddress to a health professional, involved in drug dependence treatment