Duromine is a popular in Australia brand of the appetite suppressant Phentermine. The product is manufactured by the Australian pharmaceutical company Inova.

  • Xenical is a famous brand of a specific inhibitor of gastrointestinal lipases Orlistat. This drug is produced by the Swiss company Roche.

Both drugs are the only anti-obesity drugs, approved in the Australian Register of Therapeutic Goods (ARTG) for the treatment of obesity and overweight in adults and adolescents aged 12 years and older.

In order to understand what are the differences between these two drugs and which one is most effective, we shall compare Duromine vs Xenical in this review.

Xenical and Duromine are prescription drugs and are prescribed by a physician. At the same time, Xenical is available to many Australians without prescription.

Special benefits for the purchase of these anti-obesity drugs have the veterans, whom medical doctors can prescribe an authority prescription that allows buying these medications at the best price.

Despite the fact that both drugs are used to combat obesity in the same age groups, their main difference lies in their different mechanisms of action.

Duromine, which includes Phentermine, has an anorexigenic effect, which is based on the ability of the drug to affect the appetite centers in the hypothalamus.

To provide the anorectic effect, Duromine influences the central nervous system by increasing the amount of the neurotransmitter noradrenaline, and also by affecting the level of the neurotransmitter dopamine.

Duromine use is limited to 12 weeks, since a more prolonged use increases the risk of side effects (including drug addiction).

The action mechanism of Xenical is based on the inhibition of gastrointestinal lipase, which is involved in the breakdown and digestion of fats. Undigested fats (not less than 30%) are excreted out with the feces.

  • Unlike Duromine, Xenical action is confined to the gastrointestinal tract, and the drug has no effect on the obese patient’s CNS. Yet, it is also not devoid of side effects. To date, there is no recommended duration of use for Xenical, and the drug can be used for years.

Although both anti-obesity drugs affect the reasons that promote excess weight gain (increased appetite and high fat food), the results of the few trials have shown that Duromine monotherapy still does have a slight advantage to Xenical.

It was shown that the use of Duromine 30mg per day for 12 weeks promotes a more intensive weight loss, than the administration of Xenical 120mg capsules three times a day.

The trials showed that the anorexigenic effect of Duromine helps reduce weight by an average of 3.6 kg (in 12 weeks), whereas the use of Xenical gives more modest results, averaging from 2.1 to 3.5 kg (in 12 months).

Xenical 120 mg Oral use capsules

It should be borne in mind that Xenical should be administered only when the obese patient’s meal includes fatty foods. 

Otherwise, the drug will have no effect. Of course, this does not mean that you must increase the amount of fatty foods while taking this drug.

If the daily nutrition of the patient consists of foods with a low fat content, he should better choose Duromine (unless contraindicated), because Xenical can prove ineffective.

When choosing Duromine or Xenical, you should be aware that each drug has its contraindications.

Thus, if a patient has pulmonary artery hypertension, severe cardiac disease or glaucoma, the use of the appetite suppressant Duromine is not recommended.

If this is the case, he can choose the inhibitor of gastrointestinal lipases Xenical. However, the Australians should take into account the fact that Xenical is not included in the Pharmaceutical Benefits Scheme (PBS), so the cost of this drug can be quite high.

The average cost of Xenical in Sydney drugstores is $ 68 for a 2-week supply (42 capsules). At the same time, Xenical is in Repatriation Pharmaceutical Benefits Scheme (RPBS) for Veterans. They can buy Xenical at a discounted price: 84 capsules Xenical will cost $ 6.20*.

Duromine is not on PBS or RPBS and the drug cost depends mainly on its dosage. 30 capsules of Duromine 15 mg cost $ 90, Duromine 30 mg – $ 100, Duromine 40 mg – $ 120*.
* Prices shown are valid for 2012-2013.

If an obese person has Medicare Australia state insurance, the costs for purchase Duromine can be subsidized by the state.

Under certain circumstances (for example, if the annual income is lower than the average Australian income, retirement age), an obese person may receive the government subsidies and get Duromine or Xenical capsules at a low price or for free.

  • In conclusion, Xenical is the only approved weight loss medication for long-term obesity treatment in Australia. Duromine should only be used for short-term obesity treatment.

Before you make a choice in favor of one or another anti-obesity drug, you should discuss with your doctor the cost of therapy, benefits and possible side effects of both drugs.