Duromine represents one of the most popular and effective drugs for weight loss. However, you can get rid of extra kilos not only with this anorectic, but also drugs of other pharmaceutical classes.

  • Besides Duromine, an effective weight loss is promoted by gastric lipase inhibitor Alli and the of analog glucagon-like peptide-1 (GLP-1) Saxenda.

Duromine is an anorectics and a nervous system stimulant that is used for the treatment of obesity.

  • The spectrum of its pharmacological effects includes stimulation of the release of the neurotransmitters norepinephrine and dopamine.
  • The accumulation of neurotransmitters in the hypothalamus contributes to the anorectic effect.

Unlike Duromine, Alli has not a central, but a peripheral action. The drug is an inhibitor of gastrointestinal lipases, which are the key enzymes, required for fat absorption.

Under the action of Alli, about 30% of fat consumed with food are not digested, and are excreted from the body.

While the dosage form of Duromine and Alli are capsules, Saxenda is a drug, which is introduced into the body via subcutaneous injections.

Saxenda is an analogue of GLP-1. This hormone is secreted in response to food intake and slows the production of hydrochloric acid in the stomach. Saxenda slows gastric motility and increases the feeling of fullness.

Patients should take Duromine capsules or Saxenda injections once a day. If you are using Alli, you should take one capsule with each main meal.

Since all three medications for weight loss have different action mechanisms, they differ in the duration of application:

Duromine – 3 monthsAlli – 6 monthsSaxenda – more than 1 year

Despite their different mechanisms of action, all three drugs for the treatment of obesity have a favorable “risk-benefit” ratio. Duromine, Alli and Saxenda successfully passed clinical trials, which confirmed their efficacy for weight loss.

Despite their different mechanisms of action, all three drugs for the treatment of obesity have a favorable “risk-benefit” ratio. Duromine, Alli and Saxenda successfully passed clinical trials, which confirmed their efficacy for weight loss.

Duromine, Alli and Saxenda meet all the criteria of effective drugs for weight loss:

  • Loss of at least 5% of the initial body weight
  • Long-term maintenance of the ideal weight after the end of drug therapy
  • Improve the condition in presence of additional risk factors (diabetes, hypercholesterolemia, hypertension, and others)

Each of the weight loss drugs has its own list of contraindications.

Alli and Saxenda are forbidden during pregnancy. Safe use of Duromine during pregnancy also doesn’t have a sufficient amount of confirmed clinical data.

Each of these anti-obesity drugs can cause certain side effects.

After the use of Duromine, these are mainly adverse reactions from the nervous and cardiovascular systems. Since Saxenda affects blood sugar levels, the most frequent side effect in the drug use is hypoglycemia.

Alli has a better safety profile, than Duromine and Saxenda.

Since the drug has no systemic impact over the body, its adverse reactions are limited by the symptoms of the gastrointestinal tract, such as abdominal pain, diarrhea or flatulence.

Rational use of medicines (RUM) involves the choice of a weight loss drug that would meet individual needs of each patient. For example, the prescription of Duromine or Saxenda is suitable for obese patients with associated risk factors, like diabetes, hypertension or dyslipidemia.

  • Patients who want to lose weight, but can not give up fatty and high-calorie food, can use Alli.
  • Patients on Alli can reduce the dose of statins, because this anti-obesity drug helps reduce blood cholesterol levels.

Pharmacotherapy plays a special, yet not a fundamental role in the obesity treatment. Regardless of which weight loss drug you use, indispensable parts of a weight loss program are weight loss diet and increased physical activity.